腸道菌群在慢性腎臟病伴隨骨質疏鬆症中所扮演的致病角色

在臨床上，慢性腎臟病－礦物質與骨病（chronic kidney disease-mineral and bone disease, CKD-MBD）是CKD常見的併發症，發生於病程的早期，與骨質流失與骨折的發生有關，使得CKD-MBD的發病率與死亡率增加。腸道菌群是指生活在宿主消化道內與宿主共生的微生物。腸道菌群所引起的骨質疏鬆的分子致病機制主要包括有：一、腸道屏障與營養吸收；二、免疫調節作用；三、腸－腦軸的相互調節。此外，外源性益生菌攝取可以減少尿毒症的進行，對於維持骨骼健康以及減少CKD患者的骨質疏鬆症有著密切關係。

關鍵字

腸道菌群；尿毒性骨質疏鬆症；慢性腎臟病－礦物質與骨病；免疫調節；腸－腦軸

並列摘要

Chronic kidney disease-mineral and bone disease (CKD-MBD) is a common complication of CKD, which occurs in the early stages of the disease course and is related to bone loss and fracture occurrence. The morbidity and mortality of CKD-MBD are very high. Gut microbiota refers to the microorganisms that live in the human digestive tract and symbiotically with the human body. In recent years, a large number of clinical studies on the relationship between gut microbiota and bone metabolism are being carried out. The molecular pathogenesis of osteoporosis caused by gut microbiota mainly includes: 1. Intestinal barrier and nutrient absorption; 2. Immunomodulation; 3. Mutual regulation of the intestine-brain axis. In addition, the intake of probiotics can reduce the progress of uremia, which is closely related to the maintenance of bone health and the reduction of osteoporosis in CKD patients.

並列關鍵字

gut microbiota ； uremic osteoporosis ； CKD-MBD ； immunoregulation ； gut-brain axis

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