抗腎絲球基底膜腎炎的最新治療

Treatment of Anti-Glomerular Basement Membrane Antibody Glomerulonephritis

陳紀瑜(Chi-Yu Chen) ； 黎思源(Szu-Yuan Li)

《腎臟與透析》 34卷4期 (2022/12) Pp. 188-192

https://doi.org/10.6340/KD.202212_34(4).0007

摘要

抗腎絲球基底膜腎炎是因自體抗體攻擊腎絲球基底膜所造成的一種小血管性血管炎，大概占新月形腎炎的10%～20%。而當腎炎合併肺泡出血時就會被稱作古巴斯捷氏病。當懷疑病人可能有抗腎絲球基底膜腎炎時，快速的診斷且給予病患cyclophosphamide合併類固醇的免疫藥物治療，搭配血漿置換，能大幅的拯救病患生命且避免腎臟衰竭的發生。

關鍵字

抗腎絲球基底膜腎炎 ； 古巴斯捷氏病 ； 血漿置換

並列摘要

Anti-glomerular basement membrane (Anti-GBM) antibody glomerulonephritis (GN) is a small vessel vasculitis in which circulating antibodies are directed against an antigen intrinsic to the GBM, and accounts for about 10% to 20% of crescentic GN. When Anti-GBM GN combines with pulmonary hemorrhage, it is called Goodpasture disease. If we suspect the patient has anti-GBM disease, diagnosis should be made without delay. Initiating immunosuppressants with cyclophosphamide and glucocorticoids plus plasmapheresis in all patients with anti-GBM GN is lifesaving and helps prevent kidney failure.

並列關鍵字

anti-GBM antibody glomerulonephritis ； Goodpasture disease ； plasmapheresis