- 期刊
Metronidazole與Amoxicillin兩種抗生素合併使用對治療牙周病之臨床效果探討
The Clinical Efficacy of Metronidazole Plus Amoxicillin in Treating Periodontitis: The Current Evidence
摘要
研究發現metronidazole與amoxicillin兩種抗生素具有協同作用，可有效抑制牙周致病菌Actinobacillus actinomycetemcomitans (A. a.)，因而臨床上被應用於對受A. a.感染之嚴重性牙周炎病患之輔助性治療。本文乃整理及討論以此兩種藥物合併治療方式之臨床療效報告，以作為治療時選擇藥物的參考。結果以目前之證據顯示，以機械性清除合併服用metronidazole與amoxicillin，能壓制牙齦下A.a.之數量至少達12個月，但Porphyromonas gingivalis在治療後卻仍會存在或會再出現於囊袋中，因此若病患並無A.a.之感染，則選擇metronidazole與amoxicillin效果，可能並不顯著，而且在選擇藥物同時，建議也應考慮國人之牙周病細菌之狀況及服用抗生素之習慣。
並列摘要
The purpose of this article is to summarize for the clinicians some of the clinical findings of metronidazole plus amoxicillin as an adjunctive treatment of Acinobacillus actinomycetemcomitans (A.a) associated periodontitis. Combination of the two drugs is used based on the synergistic effect of the drugs in suppressing the subgingival flora of A.a. The current evidence supports the suppression of A.a. from the entire oral cavity below detectable levels over a minimum of 12 months. Although the antimicrobial therapy may also suppress P. gingivalis in subgingival flora, long term elimination is rare due to the re-colonization of the pathogen. However, it is emphasized that the clinician should consider the periodontal flora of Chinese population and the presence of resistant strains in selecting an appropriate antibiotic for the patients.
延伸閱讀
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