骨形成蛋白調控骨生成之機轉暨應用於牙周組織再生

骨缺損的修復通常是藉由骨細胞本身在自然情況下再生的能力而達到癒合的效果，但當骨頭缺損的範圍過大，骨細胞自我修復的能力會受到限制，必須依賴外科手術植入填充物來幫助骨癒合。這樣的治療會受到一定程度的限制，尤其當患者年紀過長時，骨細胞再生的能力與外科手術治療所造成生活上的不便，會造成治療效果不彰。過去的研究報告顯示，缺乏足夠數量的造骨幹細胞或先驅細胞，甚至組織支架及生長因子的不足，都影響骨癒合的結果。近年來幹細胞結合組織工程研究使得再生醫學在骨頭再生有廣泛討論及應用潛力。有鑑於牙周組織的再生乃是再生醫學的先驅典範，因此本文以回顧整理骨形成蛋白與骨生成相關之機轉，探討應用於骨再生醫療之可行性。臨床使用DFDBA中骨形成蛋白的量無法量化，因此難以預測其牙周組織再生效果。直接使用合成之骨形成蛋白是值得進一步研究的課題，但必須有更多的研究才能應用在臨床治療。在本篇回顧短文，我們將重點專注於骨形成蛋白參與骨形成過程所引發一連串的訊息作用途徑，評估應用於骨或牙周組織再生之潛力。

關鍵字

骨形成蛋白；幹細胞；造骨細胞；再生醫學

並列摘要

The orthopedic defect usually is capable to heal spontaneously but the repairing or regenerating power of the orthopedic defect is not enough to fill up the gap if the defect is too big to regenerate. Surgical intevention with exogenous filling material aims to help the repair of the bony defect. This treatment modality bears some limitation especially for the aging people with poor prognosis and spent too much time to jeopardize their quality of life. Previous study revealed that the lack of enough stem or progenitor cells, tissue scallfold and growth factors resulted in incomplete bone healing. Recently, stem cells in combination with tissue engineering enable the regenerative medicine to apply innovative strategy and material to facilitate bone healing. Periodontal regeneration is the hallmark and pioneering of regenerative medicine. It is difficult to predict the clinical outcome for the DFDBA regeneration protocol due to the variation of BMPs content. Alternatively, the recombinant BMPs provide another approach, we can take this advantage to regenerate the alveolar bone or regenerate new cementum through BMPs directly. However, more research is necessary to do so. In this mini-review, we will focus on the potential signal pathways of BMPs in modulation the bone formation and regeneration.

並列關鍵字

bone morphogenic protein ； stem cell ； osteoblast ； regenerative medicine

國際替代計量

骨形成蛋白調控骨生成之機轉暨應用於牙周組織再生

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