Acute dissection of the aorta is one of the most dramatic of cardiovascular emergencies. Its symptoms can occur abruptly and progress rapidly. Prompt recognition and appropriate intervention is crucial. However, not all aortic dissections present with classic symptoms of abrupt chest, back, or abdominal pain, and therefore the condition may be misdiagnosed. Aortic dissection presenting as a sore throat is quite unusual. A 53-year-old man presented with sore throat as the early symptom of an acute thoracic aortic dissection. Unfortunately, the diagnosis was not made in time and the patient died. Given the high morbidity and mortality associated with acute dissection if it is misdiagnosed, aortic dissection should be considered a differential diagnosis if a patient presents with sore throat and normal neck and throat findings, even when there are no classic symptoms.