Determinants are very efficient computational method to solve system of linear equations (Cramer’s rule, the determinant of 2-by-2 matrix is the product of entries on the main diagonal minus the product of the other entries. Thus 2-by-2 determinants can usually be computed mentally. In principle, any determinant can be calculated from the formula of expansion, but this involves formidable amounts of arithmetic if the dimension is at all large. We need a new method of calculation and prove it, which is similar in 2-by-2 cases and involves less arithmetic than the methods of Laplace expansion and Gaussian Elimination.