Predictors of Change in Exercise Capacity after Simple outpatient-based Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease

胸腔復原運動對於慢性阻塞性肺病患者之運動能力改善之預估因子

卓秀英(Hsiu-Ying Cho) ； 藍冑進(Chou-Chin Lan) ； 陳英仁(Ying-Jen Chen) ； 吳孟芳(Meng-Fang Wu) ； 林玫君(Mei-Chun Lin) ； 蕭秀鳳(Hsiu-Feng Hsiao) ； 黃崇旂(Chung-Chi Huang)

《呼吸治療》 8卷2期 (2009/07) Pp. 27-38

https://doi.org/10.6269/JRT.2009.8.2.03

摘要

Introduction: Patients with chronic obstructive pulmonary disease (COPD) often experience decreased exercise capacity and quality of life (QoL). Pulmonary rehabilitation programs (PRPs) can improve exercise capacity, QoL and dyspnea in COPD patients, but little is known about the predictive factors associated with the change in exercise capacity after PRPs. The aims of this study were to confirm the benefits of PRPs and define the predictive factors associated with the change in exercise capacity after PRPs.
Methods: 43 patients of COPD were arranged to our PRPs. The baseline and post-PRP status were evaluated with spirometry, 6MWD, cardiopulmonary exercise test, and St. George's Respiratory Questionnaire (SGRQ). Stepwise multiple regression analysis was used to evaluate factors predictive of change in the 6MWD.
Results: After 6 weeks of PRPs, there were significant improvements in 6MWD (from 461.1±86.2 m to 505.5±78.4 m, p＜0.001), peak VO2 (from 15.0±3.8 ml/min/kg to 16.8±4.2 ml/min/kg, p＜0.05), maximal work rate (from 73.5±22.3 watt to 78.0±22.0 watt, p ＜0.05) and scores on the SGRQ (total, activity, symptoms and impact, all p＜0.001). Stepwise multiple regression analysis revealed that SGRQ activity, body weight, age, peak oxygen pulse (O2P) and PETCO2 were significant determinants of change in exercise capacity.
Conclusions: PRPs are effective in patients with COPD in increasing exercise capacity and QoL. Baseline SGRQ activity, body weight, age, peak O2P and PETCO2 significantly contribute to the change in exercise capacity after PRPs.

關鍵字

胸腔復原運動 ； 慢性阻塞性肺病 ； 運動能力 ； 六分鐘走路測試、運動心肺功能

並列摘要

Introduction: Patients with chronic obstructive pulmonary disease (COPD) often experience decreased exercise capacity and quality of life (QoL). Pulmonary rehabilitation programs (PRPs) can improve exercise capacity, QoL and dyspnea in COPD patients, but little is known about the predictive factors associated with the change in exercise capacity after PRPs. The aims of this study were to confirm the benefits of PRPs and define the predictive factors associated with the change in exercise capacity after PRPs.
Methods: 43 patients of COPD were arranged to our PRPs. The baseline and post-PRP status were evaluated with spirometry, 6MWD, cardiopulmonary exercise test, and St. George's Respiratory Questionnaire (SGRQ). Stepwise multiple regression analysis was used to evaluate factors predictive of change in the 6MWD.
Results: After 6 weeks of PRPs, there were significant improvements in 6MWD (from 461.1±86.2 m to 505.5±78.4 m, p＜0.001), peak VO2 (from 15.0±3.8 ml/min/kg to 16.8±4.2 ml/min/kg, p＜0.05), maximal work rate (from 73.5±22.3 watt to 78.0±22.0 watt, p ＜0.05) and scores on the SGRQ (total, activity, symptoms and impact, all p＜0.001). Stepwise multiple regression analysis revealed that SGRQ activity, body weight, age, peak oxygen pulse (O2P) and PETCO2 were significant determinants of change in exercise capacity.
Conclusions: PRPs are effective in patients with COPD in increasing exercise capacity and QoL. Baseline SGRQ activity, body weight, age, peak O2P and PETCO2 significantly contribute to the change in exercise capacity after PRPs.

並列關鍵字

Exercise capacity ； pulmonary rehabilitation programs ； six-min walk test ； cardiopulmonary exercise test ； COPD