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摘要


自從18世紀末氧氣被發現並分離以來已有超過兩百年的歷史,是目前被應用最廣泛的醫療氣體,被大量的使用於臨床上。雖然”低氧”(hypoxia) 對生物體的負面影響已經有非常多的研究與討論,但低氧(或稱缺氧)是否對人體百害而無一益?已有越來越多的科學證據顯示低氧可以透過一種現在被稱爲”預處理”的機轉對生物體提供保護作用。本篇文章旨在經由文獻回顧,透過現有的微觀的科學證據,對低氧預處理的歷史緣由、可能的潛在分子機轉與相關的臨床應用做一初步的探討。

並列摘要


Among all gases, oxygen is the most known, most extensively used gas in clinical setting. Hypoxia is a condition in which the body as a whole (generalized hypoxia) or region of the body (tissue hypoxia) is deprived of adequate oxygen supply. However, aside from its many detrimental effects on organisms, hypoxia may also exerts its beneficial effects on individuals through a mechanism known as preconditioning. In this literature review, we sought to examine the historic aspect, several possible underlying molecular mechanisms, and clinical application perspective to ”hypoxic preconditioning”

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