以呼氣濃縮物高敏感度C反應蛋白濃度做為氣喘孩童呼吸道發炎反應之指標

台灣孩童的氣喘（asthma）盛行率有逐年增加的趨勢，近年發展以非侵入性的呼氣指標檢測，做為評估氣喘孩童呼吸道發炎反應程度之參考。至目前為止，人體血液的發炎指標物與呼氣指標物之間的關係仍不清楚。本文搜集呼氣指標物與肺功能之間相關文獻進行探討，發現呼氣一氧化氮（exhaled nitric oxide, eNO）濃度分別與氣喘嚴重度、病情控制狀況、類固醇藥物及短效型β_2支氣管擴張劑的使用情形、血液高敏感度C反應蛋白濃度（high sensitivity C-reactive protein, hs-CRP）有關，而氣喘病人的呼氣濃縮物hs-CRP濃度亦與eNO濃度有關。此外，研究指出氣喘控制不良病人的呼氣濃縮物hs-CRP濃度明顯高於氣喘控制穩定病人及健康人，且氣喘病人在運動前後的呼氣濃縮物hs-CRP濃度與eNO濃度呈現明顯正相關。由於目前缺乏有關氣喘孩童呼氣濃縮物hs-CRP濃度分佈的研究，將值得未來研究進行探討。

關鍵字

氣喘；呼氣濃縮物；高敏感度C應蛋白；呼氣一氧化氮；肺功能

並列摘要

The prevalence of asthma in Taiwan has been rising in recent years. Non-invasive exhaled breath condensate (EBC) monitoring has developed as an indicator of airway inflammation in asthmatic children. To date, the correlation of the inflammatory indictors in the blood and in the exhaled condensate is unclear. The purpose of this review article was to discuss the relationship between exhaled gas indices and pulmonary function. Studies have reported changes of exhaled nitric oxide (eNO) concentration correlate with severity of asthma, disease control of asthma, the use of inhaled steroids and short-acting β_2 agonists, and the concentration of high sensitivity C-reactive protein (hs-CRP) in the serum. The concentration of EBC hs-CRP was associated with the eNO level in asthmatic patients. Additionally, concentrations of EBC hs-CRP in poor controlled asthmatic patients were higher than those in stable asthmatic patients and healthy subjects. A positive correlation existed between concentrations of EBC hs-CRP and eNO before and after exercise. Further studies are desired on the concentration of EBC hs-CRP in asthmatic children.

並列關鍵字

asthma ； exhaled breath condensate ； high sensitivity C-reactive protein ； exhaled nitric oxide ； pulmonary function

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以呼氣濃縮物高敏感度C反應蛋白濃度做為氣喘孩童呼吸道發炎反應之指標

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