A Comparison of the Diagnostic Sensitivity and Specificity of Two Anti-cyclic Citrullinated Peptides (CCP1 and CCP2) Tests for Rheumatoid Arthritis

第一代與第二代抗環瓜氨酸抗體(CCP1 and CCP2)對類風濕性關節炎的敏感度及特異性之比較

劉峰誠(Feng-Cheng Liu) ； 陳相成(Hsiang-Cheng Chen) ； 張德明(Deh-Ming Chang) ； 陳政宏(Chen-Hung Chen) ； 侯宗昀(Tsung-Yun Hou) ； 郭三元(San-Yuan Kuo) ； 賴振宏(Jenn-Haung Lai)

《Formosan Journal of Rheumatology》 20卷1&2期 (2006/12) Pp. 19-24

https://doi.org/10.6313/FJR.2006.20(1-2).03

摘要

前言：抗環瓜氨酸抗體anti-citrullinated peptide (CCP)在診斷風濕性關節炎被認爲是一種有用的檢驗工具。這時，我們將40位類風濕性關節炎病患使用抗環瓜氨酸抗體來檢查，分別比較以ELISA爲基礎的anti-CCP1及EliA爲基礎的anti-CCP2的敏感度及特異性。材料與方法：79名關節病變的患者同時以Anti-CCP1 和anti-CCP2 抗體做測試，並區別類風濕性關節炎與非類風濕性關節炎的敏感度、特異性、陽性預測值和陰性預測值。結果：Anti-CCP1和anti-CCP2在診斷類風濕性關節炎有極相似的特異性。然而，anti-CCP2與anti-CCP1之間並無明顯的相關性。結論：Anti-CCP比傳統的IgM-RF更具敏感度及特異性。但anti-CCP2 在類風濕性關節炎診斷上並沒有比anti-CCP1來得好。

關鍵字

抗環瓜氨酸抗體 ； 類風濕性關節炎

並列摘要

The detection of anti-cyclic citrullinated peptide (CCP) autoantibodies has been considered a useful tool to identify rheumatoid arthritis (RA) patients. Here, we examined the sensitivity and specificity of two detection methods, namely the ELISA-based (anti-CCP1) and the EliA-based (anti-CCP2) for anti-CCP in 40 RA patients. Methods. Anti-CCP1 and anti-CCP2 antibody tests were performed on 79 patients with arthropathy. The sensitivity, specificity, positive predictive value, and negative predictive value for-discriminating between rheumatoid arthritis (RA) and non-RA were calculated for both tests. Results. Both anti-CCP1 and anti-CCP2 shared very similar specificities (97.4%) toward diagnosing RA. However, there was no significant associations between the titer of anti-CCP1 and anti-CCP2. Conclusion. Anti-CCP test was more sensitive and specific than traditional IgM-RF. However, anti-CCP2 was not significantly better than anti-CCP1 in the diagnosis of RA.

並列關鍵字

Anti-cyclic citrullinated peptides ； rheumatoid arthritis