TNF-alpha-308A Allele is Associated with the Presence of Tophi: A Preliminary Study

甲型腫瘤壞死因子促進因子基因－308位置之G→A對偶基因多型性和痛風石的形成相關

蘇昱日(Ben Yu-Jih Su) ； 鄭添財(Tien-Tsai Cheng) ； 賴漢明(Han-Ming Lai) ； 陳英州(Ying-Chou Chen) ； 邱俊凱(Chun-Kai Chiu) ； 尤珊富(Shan-Fu Yu) ； 林科名(Ko-Ming Lin) ； 蘇富美(Ming-Chi Yang) ； 楊名琦(Fu-Mei Su) ； 陳忠仁(Chung-Jen Chen)

《Formosan Journal of Rheumatology》 21卷2期 (2007/12) Pp. 34-39

https://doi.org/10.6313/FJR.2007.21(02).06

摘要

Objective: To investigate the relationship between the presence of tophi and the TNF-alpha (TNFα) promoter-308G/A polymorphism in gouty patients.
Methods: Thirty-seven gouty patients with any visible or palpable tophi on the four limbs joints were recruited as study subjects, and 40 gouty patients without visible or palpable tophi were recruited as controls. We collected and analyzed the clinical characteristics and laboratory data of patients in both groups. The TNFα-308G/A polymorphism was analyzed by PCR-RFLP methods.
Results: There was no statistically significant difference in personal history, family history of gout or baseline laboratory data between patients with tophi and those without. There were statistically significant differences in favor of developing tophi in the heterozygote TNFα-308G/A (p=0.017, odds ratio 6.11, 95% C.I. 1.22-30.49). The frequency of the TNFα-308A allele was significantly higher in patients with tophi than in patients without (p=0.02, odds ratio 5.4, 95% C.I. 1.13-25.88). The-308 allele carriage of the G allele was 100% in both the tophi and non-tophi groups. In patients with tophi and without tophi, the-308 allele carriage of the A allele was 12.2% and 2.5%, respectively (p=0.035, odds ratio 4.87, 95% C.I. 0.99-24.00).
Conclusion: To our knowledge, this is the first study to find that the TNFα-308A allele is associated with the presence of tophi in gouty patients. Further study of other polymorphisms in the TNF promoter is indicated to understand more about the tophi.

關鍵字

痛風 ； 甲型腫瘤壞死因子 ； 基因多型性

並列摘要

Objective: To investigate the relationship between the presence of tophi and the TNF-alpha (TNFα) promoter-308G/A polymorphism in gouty patients.
Methods: Thirty-seven gouty patients with any visible or palpable tophi on the four limbs joints were recruited as study subjects, and 40 gouty patients without visible or palpable tophi were recruited as controls. We collected and analyzed the clinical characteristics and laboratory data of patients in both groups. The TNFα-308G/A polymorphism was analyzed by PCR-RFLP methods.
Results: There was no statistically significant difference in personal history, family history of gout or baseline laboratory data between patients with tophi and those without. There were statistically significant differences in favor of developing tophi in the heterozygote TNFα-308G/A (p=0.017, odds ratio 6.11, 95% C.I. 1.22-30.49). The frequency of the TNFα-308A allele was significantly higher in patients with tophi than in patients without (p=0.02, odds ratio 5.4, 95% C.I. 1.13-25.88). The-308 allele carriage of the G allele was 100% in both the tophi and non-tophi groups. In patients with tophi and without tophi, the-308 allele carriage of the A allele was 12.2% and 2.5%, respectively (p=0.035, odds ratio 4.87, 95% C.I. 0.99-24.00).
Conclusion: To our knowledge, this is the first study to find that the TNFα-308A allele is associated with the presence of tophi in gouty patients. Further study of other polymorphisms in the TNF promoter is indicated to understand more about the tophi.

並列關鍵字

Tophi ； gout ； tumor necrosis factor-alpha