This paper presents a fast and effective methodology for parameters of manufac turing process optimization of colded-rolled coil annealing. The colded-rolling coil is widely used in all over the country. Not just the metal furniture was made from colded-rolling coil, through the extra working, it also can be used to make computer case; parts of bike etc. For that reason, we use the CQ1 (Normal commercial Grade of C. R. coil) to be the material of research. The following five indications are use for decide optimal process of annealing: ratio of rolling compressed, the first stage isotherm temperature, the second stage isotherm temperature, the first stage isotherm time, The second stage isotherm time. The optimal experimental design method of this paper is that combines the gray Relational analysis method. This method can replace the traditional ”change-one-parameter-at-a-time” approach which is very powerful, costly, time consuming and almost impracticable to yield an optimum solution.