成骨細胞與破骨細胞的研究探討

The Study of Osteoblast and Osteoclast

林文彬(Wen-Ping Lin)

《中醫骨傷科醫學雜誌》 6期 (2007/12) Pp. 39-47

https://doi.org/10.30098/JCOT.200712.0008

摘要

成骨細胞是骨形成過程中的重要功能細胞。70年代中期還認爲破骨細胞與成骨細胞爲共同的祖代來源，但自80年代初開始，認識到破骨細胞來源於單核吞噬細胞系統之外的骨髓生血細胞系統，爲獨立於骨髓幹細胞系統的一個細胞系。
成骨細胞的功能是合成、分泌膠原與糖蛋白，形成骨基質；參與破骨細胞性骨吸收的調控作用；維持骨的代謝平衡。而破骨細胞是一個高度分化的多核大細胞，其主要功能爲吸收骨，成骨細胞受下列因數調節：轉化生長因數β(TGF-β)、1，25(OH)2D3、胰島素樣生長因數(IGF)、白細胞介素1(IL-I)、雌激素、腫瘤壞死因數α(TNFα)、骨形成蛋白(BMP)，骨吸收的主要調節因數有：降鈣素(CT)、甲狀旁腺激素(PTH)、前列腺素(PGs)、活性維生素D3(1,25(OH)2D3)、細胞因數、腫瘤壞死因數(TNFα、β)、干擾素(IF)、白細胞介素－18(IL-18)、白細胞介素-17(IL-17)。

關鍵字

成骨細胞 ； 破骨細胞

並列摘要

The osteoblast is important function cell in the bone forming process. The 70's middle stages also recognized that the osteoclast and the osteoblast are came from the same generation origin, but starts from the beginning of the 80's, realized that the osteoclast originated from marrow system outside the mononuclear phagocyte system, was a independent cell system of stem system.
The osteoblast function is synthesis, secretion collagen and glycoprotein, to form bone base, participate the osteoclast bone absorption regular function, maintains the bone metabolism balance. But the osteoclast is a polynuclear big cell which highly splits up, its main function is bone absorption.
Osteoblast was adjusted by following factor: Transforming Growth Factor β (TGF-β), 1,25(OH)2D3, Insulin Growth Factor (IGF), Interleukin-1 (IL-I), Estrogens, Tumor Necrosis Factorα (TNFα), Bone Morphogenetic Protein (BMP).
The main adjustment factor of bone absorption includes: Calcitonin (CT), Parathyroid Hormone (PTH), Prostaglandins (PGs), Active Vitamin D3 (1, 25 (OH)2D3), Cell Factor, Tumor Necrosis Factor (TNFα, β), Interferon (IF), Interleukin-18 (IL-18), Interleukin-17 (IL-17).

並列關鍵字

Osteoblast ； Osteoclast