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Endogenous Concentration of Prostaglandin E2 in the Human Genitourinary Tract: A Preliminary Report

前列腺素E2在人類生殖泌尿道的內因性含量:先期報告

摘要


n this study, the tissue concentration of prostaglandin E2 (PGE2)in the human genitourinary tract was detemined. A total of 38 patients who underwent surgery for different urological diseases was included in this study with consent. There were 36 males and 2 females, whose ages ranged from 6 to 86 years old (mean: 65.8 years). The tissue concentrations (mean ± S.E. ng/g tissue) of PGE2 were 92.1 ± 40.4 in the ureter, 120.9 ± 70.9 in the vas deferens, 25.9 ± 13.4 in bladder muscle, 126.7 ± 13.7 in prostatic tissue of the benign hyperplastic proseate (BPH) and 1.6 in the testis (one case only). No correlation was demonstrated between age and the PGE2 concentraion in the ureter, vas deferens, bladder muscle, prostatic tissue of BPH, or testis, respectively (Pearson coefficient correlation, P>0.05 in all). The endogenous con-centrations of PGE2 in the human genitourinary tract were significant. It might have some role in modulating the function of the human genitourinary tract.

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並列摘要


n this study, the tissue concentration of prostaglandin E2 (PGE2)in the human genitourinary tract was detemined. A total of 38 patients who underwent surgery for different urological diseases was included in this study with consent. There were 36 males and 2 females, whose ages ranged from 6 to 86 years old (mean: 65.8 years). The tissue concentrations (mean ± S.E. ng/g tissue) of PGE2 were 92.1 ± 40.4 in the ureter, 120.9 ± 70.9 in the vas deferens, 25.9 ± 13.4 in bladder muscle, 126.7 ± 13.7 in prostatic tissue of the benign hyperplastic proseate (BPH) and 1.6 in the testis (one case only). No correlation was demonstrated between age and the PGE2 concentraion in the ureter, vas deferens, bladder muscle, prostatic tissue of BPH, or testis, respectively (Pearson coefficient correlation, P>0.05 in all). The endogenous con-centrations of PGE2 in the human genitourinary tract were significant. It might have some role in modulating the function of the human genitourinary tract.

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