- 期刊
Wistar鼠單側隱睪對側己降睪丸的病理改變
Pathological Changes in the Contralateral Descended Testis of Unilateral Cryptorchidism in Wistar Rat
摘要
Unilateral cryptorchidism model was induced in Wistar rat at the age of 14 days. A shamoperative and A non-operative group were in closed control groups. Animals were sacrificed at 28, 50 and 100 days old, respectively. The weight and volume of testes, mean seminiferous tubule diameter (MSTD), testicular biopsy score (TBS) and DNA of germ cells were recorded. At the ages of 28 and 50 days, there was no difference in weight and wolulme of testes, MSTD and TBS between the contralateral descended testis (CDT) and the left testis of two control groups (P＞0.05). At the age of 100 days, there was no difference in weight and volume between CDT and the left testis of two control groups, But the MSTD of CDT was 253.5 ± 36.1 µm, TBS was 3.63 ± 0.52 points; In the left testis of the non-operative and sham-operative groups, MSTD was 303.3 ± 17.7 µm V303.0 ± 16.6 µm; TBS was 9.58 ± 0.24 point V9.60 ± 0.14 points. There was a significant difference in MSTD and TBS between CDT and the left testis the two control groups (P＜0.01). Using flow cytometry (FCM) to measure changes in DNA of germ cells, at the age of 28 days, diploid (2C) in CDT was 30.08 ± 9.97%; 2C in the left testis of the nonoperative group was 75.51 ± 1.76%, there was a significant difference (P＜0.01). At the age of 50 and 100 days, haploid (1C) in the left testis of the non-operative group was 64.39 ± 10.42% V60.4 ± 3.45%respectively, In conclusion, these changes in CDT probable belong to the secondary degenerative lesion of cryptorchidism.
並列摘要
Unilateral cryptorchidism model was induced in Wistar rat at the age of 14 days. A shamoperative and A non-operative group were in closed control groups. Animals were sacrificed at 28, 50 and 100 days old, respectively. The weight and volume of testes, mean seminiferous tubule diameter (MSTD), testicular biopsy score (TBS) and DNA of germ cells were recorded. At the ages of 28 and 50 days, there was no difference in weight and wolulme of testes, MSTD and TBS between the contralateral descended testis (CDT) and the left testis of two control groups (P＞0.05). At the age of 100 days, there was no difference in weight and volume between CDT and the left testis of two control groups, But the MSTD of CDT was 253.5 ± 36.1 µm, TBS was 3.63 ± 0.52 points; In the left testis of the non-operative and sham-operative groups, MSTD was 303.3 ± 17.7 µm V303.0 ± 16.6 µm; TBS was 9.58 ± 0.24 point V9.60 ± 0.14 points. There was a significant difference in MSTD and TBS between CDT and the left testis the two control groups (P＜0.01). Using flow cytometry (FCM) to measure changes in DNA of germ cells, at the age of 28 days, diploid (2C) in CDT was 30.08 ± 9.97%; 2C in the left testis of the nonoperative group was 75.51 ± 1.76%, there was a significant difference (P＜0.01). At the age of 50 and 100 days, haploid (1C) in the left testis of the non-operative group was 64.39 ± 10.42% V60.4 ± 3.45%respectively, In conclusion, these changes in CDT probable belong to the secondary degenerative lesion of cryptorchidism.
延伸閱讀
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