Successful Chemolysis of Renal Uric Acid Stone by Oral Potassium Citrate

以口服Potassium Citrate成功溶解腎臟尿酸結石

王世農(Sing-Nong Wang) ； 李瀛輝(Ying-Huei Lee) ； 黃榮慶(Jong-Khing Huang)

《中華民國泌尿科醫學會雜誌》 6卷2期 (1995/06) Pp. 108-111

https://doi.org/10.7024/JUAROC.199506.0108

摘要

我們遇到一個由超音波，靜脈腎盂攝影及腹部電腦斷層證實之左側腎臟尿酸結石。此病人尿液酸鹼值偏向酸性。在服用U-Citra（包含檸檬酸鉀及檸檬酸）兩個月，結石及症狀完全消失。尿中非解離性尿酸含量降低（每日尿酸排泄量：612毫克）。檸檬酸鉀能提供鹼以鹼化尿液及尿液檸檬酸反應。同時也藉由降低尿液尿酸飽和度及其本身之抑制作用來妨礙鈣鹽及尿酸結晶形成。結果顯示以檸檬酸鉀鹼化尿液是治療結石的有效方法。

關鍵字

尿路結石 ； 檸檬酸 ； 尿酸結石

並列摘要

A case of uric acid stone (4×2.5 cm) of the left renal pelvis, was demonstrated by sonography, excretory urography and abdominal computer tomography. The urine pH of the patient tended to be acidic. Two months after the start of alkalization of the patient’s urine by U-Citra (potassium citrate and citric acid), both urolithiasis and the symptoms disappeared completely. The amount of undissociated urinary uric acid decreased (UA: 612 mg/day). Potassium citrate delivered an alkali load, urinary alkalization and citraturic response and retarded the propensity for the crystallization of calcium salts and uric acid by decreasing the urinary saturation and/or increasing the inhibitor activity. The result demonstrated that alkalization of urine by potassium citrate is an effective treatment for uric acid stone.

並列關鍵字

urinary calculi ； citrate ； uric acid calculi