以免疫組織化學法則測定膀胱移行上皮癌組織胚胎抗原(CEA)在臨床病理的相關性

陳黎明(Lia-Beng Tan) ； 簡崇和(Chong-Ho Chien) ； 江金培(Chin-Pei Chiang) ； 黃俊雄(Chun-Hsiung Huang) ； 周以和(Yii-Her Chou) ； 王起杰(Chii-Jye Wang)

《中華民國泌尿科醫學會雜誌》 9卷4期 (1998/12) Pp. 179-185

https://doi.org/10.7024/JUAROC.199812.0179

摘要

Immunoperoxidase method was used to study the tumor expression of carcinoembryonic an-tigens (CEA) in 61 patients with transitional cell carcinoma of the urinary bladder. In our study, the presence of CEA I ncancer tissues orrelates well with the tumor stage. CEA was positive in 30% of superficial tumor tissue, and 48% of invasive cases (P＜0.05). There is a significant correlation between CEA expression and differentiation of the tumor; in well-differentiated tumors, CEA was found in the tumor tissue in 17% of cases, however, 42% of poorly differentiated carcinomas were CEA-positive. (P＜0.05).
Among the 30 patients in this study (9 were CEA positive and 21 had CEA negative) with superficial tumors, 18 of them developed recurrent tumors after surgery, and among these 5(55%) were CEA postitive and 13 (62%) were CEA negative (P＜0.05). Two (40%) of 5 CEA-postitive cases and 2 (16%) pf 16 CEA-negative cases subsequently developed invasive tumors, indicating that patients with CEA positive were more liable to develop invasive tumors (P＜0.05). A signify-cant correlation (P＜0.05) was also observed between the presence of CEA and the prognosis. In this study, 5(20%) of the 24 patients with CEA-positive tumors lived for more than 5 yr; in contrast,26 (70%) of the 37 CEA-negative patients live for more than 5 yr.

關鍵字

癌胚胎抗原 ； 膀胱癌 ； 預後。

並列摘要

Immunoperoxidase method was used to study the tumor expression of carcinoembryonic an-tigens (CEA) in 61 patients with transitional cell carcinoma of the urinary bladder. In our study, the presence of CEA I ncancer tissues orrelates well with the tumor stage. CEA was positive in 30% of superficial tumor tissue, and 48% of invasive cases (P＜0.05). There is a significant correlation between CEA expression and differentiation of the tumor; in well-differentiated tumors, CEA was found in the tumor tissue in 17% of cases, however, 42% of poorly differentiated carcinomas were CEA-positive. (P＜0.05).
Among the 30 patients in this study (9 were CEA positive and 21 had CEA negative) with superficial tumors, 18 of them developed recurrent tumors after surgery, and among these 5(55%) were CEA postitive and 13 (62%) were CEA negative (P＜0.05). Two (40%) of 5 CEA-postitive cases and 2 (16%) pf 16 CEA-negative cases subsequently developed invasive tumors, indicating that patients with CEA positive were more liable to develop invasive tumors (P＜0.05). A signify-cant correlation (P＜0.05) was also observed between the presence of CEA and the prognosis. In this study, 5(20%) of the 24 patients with CEA-positive tumors lived for more than 5 yr; in contrast,26 (70%) of the 37 CEA-negative patients live for more than 5 yr.

並列關鍵字

carcinoembryonic antigen ； bladder tumor.