- 期刊
多發性原發惡性腫瘤－病例報告
Multiple Primary Malignant Neoplasms - Case Report
摘要
多發性原發惡性腫瘤的病例並不少見，然而不論是同時發生或不同時間發生的惡性腫瘤，都很少超過5種。台中榮總耳鼻喉科於1985年7月間經歷一名43歲女性的喉癌病人，先後於10年間罹患子宮頸癌、喉癌、皮膚癌、乳癌、膀胱癌及肺癌等6種不同器官的惡性腫瘤，而且都不是轉移性的病灶。各種腫瘤對於當時的治療方法都有很好的療效。病人沒有家族遺傳的傾向，但是免疫系統卻有明顯的缺陷。因為一個人在不同時間內發生6種不同器官的惡性腫瘤，實在是罕見。故特別提出報告，以供大家參考指正。
關鍵字
多發性原發惡性腫瘤，全內視鏡檢查並列摘要
Multiple primary malignant neoplasms, either synchronous and within the same organ system or metachronous and involving multiple organ systems, are out uncommon. The reported incidence ranges from 6.5% to 35%. It is especially higher in head and neck cancer which involves the aerodigestive tract. The most common second primary tumor is in the lung or esophagus. One individual with 2 or 3 malignant neoplasms is not unusual. However, it is very rare that a patient has more than 5 primary malignancies in the lifetime. In July 1985, we encountered a 43-year0old female patient who had developed 6 metachronous primary malignant neoplasms in a period of 10 years. The sequential anatomic sites of neoplasms included the uterine cervix, larynx, skin, left breast, bladder, and right lung. All of the tumors were proven by pathologic examination and each of them was recognized as a distinct primary tumor. The patient had no familial or hereditary tendencies, but definite impairment of the cellular immunity had been found. Aggressive surgical resection, post-operative irradiation, and chemotherapy were given to this patient and the response was very good in each therapeutic modality.