Middle turbinate headache syndrome is theorized that an enlarged middle turbinate, most commonly due to pneumatization (concha bullosa), may contact the septum or lateral nasal wall and cause headaches referred from the ophthalmic division of the trigeminal nerve, the main sensory innervation of the anterior end of the middle turbinate. Middle turbinate headache syndrome is reviewed, with attention to pathophysiology, clinical presentation, and treatment. Ten cases of middle turbinate headache syndrome undergoing surgery were presented in support of this this clinical entity. Medical therapy was attempted initially in all patients, including oral decongestants, nonsteroid antiinflammatory drugs, antihistamines and topical steroid sprays. Antibiotics were prescribed in the case of concha bullosa with adscess formation. Due to no noted improvement of headache, the ten patients were suggested to undergo surgery. In the eight cases of concha bullosa, the operative procedure performed was partial resection of the lateral aspect of the middle turbinate, the medial aspect was retained and positioned so as not to contact the septum or lateral nasal wall. In the other two cases of distorted middle turbinate combined with nasal septal deviation, septoplasty and partial resection of the middle turbinate were performed. All patients undergoing surgery had complete relief of headache by 1 month postoperatively, except two patients (the case of concha bullosa wih abscess and the other case of distorted middle turbinate combined with septal deviation) who still has occasional headache, but the heasdaches occur significantly less frequently than prior to surgery. We hope to alert the clinician to a relatively unknown source of recurrent headaches that may be readily treated by otolaryngologist.