The use of CO2 laser has become more popular for the surgery of oropharyngeal lesion, because it can decrease intraoperative bleeding, postoperative pain and accelerate wound healing. But few controlled studies have been done to validate the advantages of this application. Twenty-six patients with chronic tonsillitis had been collected in Chang Gung Memorial Hospital from April 1995 to October 1995. Right tonsils were removed with electrocautery dissection and left tonsils were excised with CO2 laser vaporization. All patients didn’t know which tonsil was removed with the laser. We assessed operative time, intraoperative bleeding, postoperative pain and wound healing between two sides. The result showed that the operative time was shorter and intraoperative bleeding was less on the side of CO2 laser. Moreover, postoperative pain was rated less worse and wound healing was observed faster with the use of CO2 laser.