抗甲狀腺藥物引起之顆粒性白血球低下症－病例報告

Antithyroid Drug-induced Agranulocytosis - Case Report

李欣賢(Hsin-Hsien Lee) ； 林泰良(Tai-Liang Lin)

《中華民國耳鼻喉科醫學會雜誌》 32卷4期 (1997/08) Pp. 464-467

https://doi.org/10.6286/1997.32.4.464

摘要

甲狀腺機能亢進或甲狀腺結節，在耳鼻喉頭頸科領域中並非罕見，而抗甲狀腺藥物在耳鼻喉科門診中亦常被使用。一般而言，抗甲狀腺藥物發生副作用的比例並不高，最嚴重的副作用則是肝功能異常和顆粒性白血球低下症。特別是顆粒性白血球低下症，而發生的比率則小於0.5%。本科於民國84年12月經歷1名因服用抗甲狀腺藥物而引起顆粒性白血球低下的病例，病人以上呼吸道感染表現，因病例罕見，特提出報告。(中耳醫誌 1997;32:464-467)

關鍵字

抗甲狀腺藥物 ； 顆粒性白血球低下症 ； 甲狀腺機能亢進

並列摘要

Hyperthyroidism and thyroid nodule are not rare, and antithyroid drugs are widely used in Otolaryngologic field.
Generally speaking, the side effect of antithyroid drugs is rare. The agranulocytosis is the most severe side effect. The cause rate of agranulocytosis is less than 0.5%.
In Dec..1995, we had a case of agranulocytosis that was caused by antithyroid drugs (tapazole 10 mg/day) for 1 month. High fever, sore throat and general malaise were the symptoms. After physical examinations, acute tonsillitis and acute epiglottitis were diagnosed. And the laboratory data showed: WBC: 290 cells/mm³(Seg:3.4% Lym: 89.7% Mono: 6.9%). After antibiotics and G-CSF being used, WBC returned to 7600 cells/mm³ on the 16th hospital day. The patient recovered well under the treatments.

並列關鍵字

antithyroid drugs ； agranulocytosis ； hyperthyrodism