Perennial Allergic Rhinitis Treated with Beclomethasone Dipropionate as Aqueous Nasal Spray and Pressurized Aerosal

水溶液及氣壓式類固醇鼻噴劑治療經年性過敏性鼻炎的評估

葉德輝(Te-Huei Yeh) ； 劉嘉銘(Chia-Ming Liu) ； 李憲彥(Shiann-Yann Lee)

《中華民國耳鼻喉科醫學會雜誌》 32卷5期 (1997/10) Pp. 364-371

https://doi.org/10.6286/1997.32.5.364

摘要

背景：探討不同推進方式的局部類固醇鼻噴劑對經年性鼻過敏的療效及影響。
方法：以聲反射鼻量計與臨床指標評估水溶液或氣壓式局部類固醇的效果。
結果：顯示兩種製劑對鼻過敏的症狀均有顯著的改善;聲反射鼻量計檢查結果顯示：水溶液較氣壓式噴劑顯著的增加鼻道的通暢度;約一半的病人認為水溶液較氣壓式鼻噴劑能接受，而僅有兩名病人意見相反。
結論：水溶液鼻噴劑不僅符合環保原則，在必須長期使用鼻噴劑的患者中較能被接受，且無論患者主觀認定或客觀測量的參數均有較好的表現。

並列摘要

Background: Nasal steroid spray has been widely used as an effective treatment for allergic rhinitis. Various forms and different preparations were developed to accommodate patients’ needs. The main goal of modification is to get better effectiveness without side effect, more friendly preparation or longer drug-using interval to improve compliance. Methods: Beclomethasone dipropionate (BDP)Nasal spray has been a safe medication used in allergic rhinitis for more than a decade. In this study, we compared the acoustic rhinometric and clinical performance of a BDP aqueous solution with conventional aerosol preparation.
Results: Both nasal sprays revealed similar efficacy in controlling symptoms in comparison of baseline data (p＜0.001). In acoustic rhinometric tests, the aqueous formula significantly increased the nasal airway patency (2-7.4 cm volume measurement) than aerosol spray (p=0.004). Fifteen patients (15/31, 48%) preferred aqueous solution to aerosol spray in contrast to only 2 patients preferring the latter (Chi-Squaree test; p＜0.001).
Conclusions: The aqueous solution showed no irritating effect, higher compliance of patients in using the drug and better outcome in acoustic rhinometric test. (J Otolaryngol Soc 1997;32:364-371)

並列關鍵字

perrenial allergic thinitis ； topical steroid ； acoustic rhinometry