Aspergillosis is the most common mycosis of the paranasal sinuses with the maxillary sinus as the most frequently involved site. Isolated sphenoid aspergillo-sis is very rare. Most paranasal sinus aspergilloses are classified as non-invasive type. In 1994, Rowe-Jones and Freedman reported three cases of semi-invasive sphe-noid aspergilloses. The histopathological findings revealed no fungal mucosal inva-sion; nevertheless, clinically the lesion manifested aggressive. Three cases of semi-invasive sphenoid asperggilloses were encountered at Taichung Veterans General Hospital in may 1995 and they were presented in detail.