Chondrosarcoma occurs most often in the pelvis, femur and humerus. However, it rarely occurs in the mandible. In this paper we report a case of chondrosarcoma of the mandible. A 24-year-old woman presented with a huge painless mass over the right check for 6 months. She later developed trismus and occlusal disharmony. Physical examination revealed a bulging mass, 10 x 10 cm, on the right lower face. Wide resection and immediate reconstruction with a vascularized iliac osteocutaneous free flap were performed. The pathological diagnosis was chondrosarcoma of the mandible. The patient received postoperative radiotherapy. There has been no evidence of recurrence or metastasis on follow up.