In this research, the analysis of stress concentration problems using the boundary element method in three-dimensional plate with a hole is presented. Literature’s concerning the stress concentration problems most put emphasis on the study of two-dimensional plane cases. However, the thickness of plate affects the stress concentration factor in certain cases, for example, due to the application of out-of-plane bending and hence three-dimensional case should be considered here. It is straightforward and convenient to solve the three-dimensional stress concentration problems using computational techniques. The boundary element analysis is a powerful numerical approach since only the geometrical and physical variables on the surface of solid are involved. For another numerical approach, the finite element method must complicatedly deal with solid element modeling. To demonstrate the accuracy and efficiency of the proposed boundary element method, some benchmark problems with eight-noded isoparametric quadrilateral boundary elements are presented. For numerical results, comparisons are made with analytical solutions or other existing numerical results.