To many enterprises of small to medium size, it is an effective way to increase their competitiveness by the application of logistics consolidation that mutually shares resources and develops profit. This research studies the impact of the factors that affect the transportation cost of logistics consolidation: number and location of shipping terminals, distribution of the destination of shipping orders, discount of transportation expense, capability of transportation vehicle, receiving and shipping policies, and number and location of distribution centers. Based on the design of experiments, five simulation models are built using real data from distribution centers. Simulation results show that, by the appropriate control of the above factors, logistics consolidation can lead to a significant reduction of transportation cost.