The Improvement of Pain Symptoms and Activities of Daily Living in People with Knee Osteoarthritis after Intra-articular Hyaluronic Acid Injection

膝關節內注射玻尿酸對退化性膝關節炎患者臨床疼痛症狀及日常生活功能之效應

陳柏旭(Carl P. C. Chen) ； 陳智光(Chih-Kuang Chen) ； 陳靖倫(Max J. L. Chen) ； 林瀛洲(Yin-Chou Lin) ； 許宏志(Tony H. C. Hsu) ； 鄭如芠(Ju-Wen Cheng) ； 鄧復旦(Simon F. T. Tang)

《台灣復健醫學雜誌》 32卷3期 (2004/09) Pp. 111-116

https://doi.org/10.6315/2004.32(3)01

摘要

退化性關節炎常見於老年人，好發於承受重量的關節，其中以膝關節最常受影響。由於膝關節是承重關節並且在下肢的功能及步行上扮演著重要的角色，膝關節之退化對日常生活功能的影響是不能被忽略的。許多研究顯示，膝關節內注射玻尿酸，對於退化性膝關節炎有正面之療效。與非類固醇抗發炎藥相比，玻尿酸除了有相當的療效外，更少了腸胃道出血的副作用。本研究收錄25位在兩側退化性膝關節炎的病人，並給予連續五週在膝關節內注射玻尿酸。注射前後以李群氏指數(Lequesne's index)進行臨床疼痛症狀及日常生活功能評估。
結果顯示，經五周之玻尿酸注射後，病患之臨床疼痛症狀及日常生活功能均有明顯之進步。因此我們可推論玻尿酸之關節內注射可有效改善膝關節炎患者之臨床疼痛症狀及日常生活功能。

關鍵字

退化性關節炎 ； 玻尿酸 ； 疼痛 ； 日常生活功能

並列摘要

Osteoarthritis (OA) is a slowly evolving articular disease that appears to originate in the cartilage and affects the underlying bone, soft tissues, and synovial fluid. This condition usually occurs late in life, principally affecting the large weight-bearing joints such as the knee. It is particularly disabling when the knees are affected, because it limits the ability to walk, to rise from a chair, and to use stairs.
The treatment selections for OA knees include analgesic drugs, physiotherapy, intra-articular (IA) drug administration, and surgical total knee replacement. We chose IA hyaluronic acid injection as the treatment method as it was documented as a safe drug, and being at least as efficacious as a continuous treatment with naproxen for 26 weeks. In this study, clinical pain symptoms, and activities of daily living were assessed by using Lequesne's Index before and after IA knee hyaluronic acid injections in 25 patients with bilateral knee OA. One session of hyaluronic acid injection was given to both knees (weekly IA knee injections for a total of five weeks). Results revealed significant improvements in clinical pain symptoms, and performance of activities of daily living after the completion of IA knee hyaluronic acid injections.
Therefore, we conclude that IA knee hyaluronic acid injections are effective in alleviating the clinical pain symptoms, and improving the deteriorated activities of daily living that were caused by knee osteoarthritis.

並列關鍵字

osteoarthritis ； hyaluronic acid ； pain ； activities of daily living