A number of mechanical equipments such as elevators, compressors ventilators, vents and pipes, transformers etc., are usually installed in a building; consequently, it needs to attenuate the structure-borne noise generated by the equipments, on the other hand, to be capable of sustaining seismic load. Owing to the difference existing in the peak frequencies of mechanical vibration of the equipments and the seismic load, the required stiffness of the isolators for both vibration sources is quit different. It can be a problem to design such isolator to satisfy these two purposes simultaneously. While in this paper, a two-stage isolator is is used to satisfy these two purposes. The design consideration regarding to the dynamical stiffness and damping ratio are discussed. From the validation measurement of an application example, it shows that effectiveness in noise reduction of an amount 10~12 dB can be attained.