Immunological Studies in a Silicone Exposed Population-A One Year Follow Up Report

矽膠在人體內所產生的免疫反應－一年追蹤報告

黃耀主(Peter Huang) ； 呂旭彥(Shiuh-Yen Lu) ； 陳明庭(Ming-Ting Chen)

《中華民國重建整形外科醫學會雜誌》 5卷2期 (1996/06) Pp. 63-70

https://doi.org/10.7096/JPRSA.199606.0063

摘要

三十年前人類開始使用矽膠後，就有人懷疑矽膠對人體的安全性，但是至今還沒有一個報告能確定的告訴我們答案。
這兩年來國泰醫院針對45位不管是接受矽膠小針注射或矽膠降乳手術的女性患者，進行免疫反應的探討；發現57.5%的病人有高過正常值的ANA血清指標，其中19位病人接受手術清除矽膠所侵犯的組織，而她們的ANA血清指標在兩個月到四個月之問有明顯的下降，我們認為這個發現有助於未來在評估矽膠與人體免疫系統之間的關係。

並列摘要

Silicone was first introduced over three decades ago. Since that time, they have been used extensively for both cosmetic and reconstructive surgery. Shortly after silicone breast implants were developed, plastic surgeons became aware of some of the risks and complications associated with silicone. Controversy concerning the safety of silicone has arose wide discussions among the pros and cons. Until now, no definite answer has been found yet.
The present study was designed to determine (1) whether silicone exposure induces immunological disorder in human? (2) will the immunological disorder reverse after the removal of silicone?
A total of 45 patients received either direct silicone injections or silicone implants were evaluated by immunological screening tests. Nineteen patients undergone total or partial removal of silicone and were followed with repeat tests. Results showed high titer ANA levels in 23 patients (57.5%). For those who underwent surgery, decrease in ANA levels were observed for all patients 2 to 4 months after surgery.
These data suggest that (1) ANAs are closely associate with silicone exposure, (2) ANAs might be a reliable serological markers preceding development of any silicone-related symptoms, and (3) for those who underwent surgical removal of silicone, ANA is a good indicator for follow-up serological study.

並列關鍵字

silicone ； immunoglobulins ； complements ； rheumatoid factor ； antinuclear antigen ； lymphocyte subpopulation ； anti-DNA antigen ； autoimmune