Charcoal Hemoperfusion in Fulminant Hepatic Failure-Factors Determining Outcome of the Therapy

活性炭血液透析治療猛暴性肝衰竭－其治療預後之決定要素

李壽東(Shou-Dong Lee) ； 王覲瑜(Jiin-Yu Wang) ； 蔡養德(Yang-Te Tsai) ； 黎國洪(Kwok-Hung Lai) ； 伍偉華(Wai-Wah Ng) ； 吳肇卿(Jaw-Ching Wu) ； 楊五常(Wu-Chang Yang) ； 萬象(Shianq Wann) ； 黃東波(Tung-Po Huang) ； 羅光瑞(Kwang-Juei Lo)

《中華民國消化系醫學會雜誌》 3卷2期 (1986/06) Pp. 49-55

https://doi.org/10.6557/GJTa.198606_3(2).0001

摘要

Of 16 fulminant hepatic failure (FHF) patients treated with charcoal hemoperfusion (HP), 8 (50%) survived. Prior to HP, their serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratios, alpha-fetoprotein (AFP) levels, and prothrombin times were measured. The AST/ALT ratio was significantly higher in the fatal cases (n=8, 1.15±0.24) than in the survivors (n=8, 0.49±0.11) (p＜0.025). The AFP levels in seven patients who survived were greater than 130ng/ml, while seven of eight patients (87.5%) who died had AFP levels of less than 130ng/ml (p=00014). The prothrombin time was significantly more prolonged in the fatal cases (n=5, 29.9±2.9%) than in the survivors (n=8, 47.3±5.8%) (P＜0.05). Neither age, sex, or causal factors affected the prognosis. Charcoal HP did not appear to increase the survival rate in FHF patients with low AFP levels. Serum AFP levels, AST/ALT ratios, and prothrombin times may be useful as prognostic indices in patients with FHF.

關鍵字

猛爆性肝衰竭 ； 活性炭血液透析法 ； 甲型胎兒蛋白 ； AST/ALT比率

並列摘要

Of 16 fulminant hepatic failure (FHF) patients treated with charcoal hemoperfusion (HP), 8 (50%) survived. Prior to HP, their serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratios, alpha-fetoprotein (AFP) levels, and prothrombin times were measured. The AST/ALT ratio was significantly higher in the fatal cases (n=8, 1.15±0.24) than in the survivors (n=8, 0.49±0.11) (p＜0.025). The AFP levels in seven patients who survived were greater than 130ng/ml, while seven of eight patients (87.5%) who died had AFP levels of less than 130ng/ml (p=00014). The prothrombin time was significantly more prolonged in the fatal cases (n=5, 29.9±2.9%) than in the survivors (n=8, 47.3±5.8%) (P＜0.05). Neither age, sex, or causal factors affected the prognosis. Charcoal HP did not appear to increase the survival rate in FHF patients with low AFP levels. Serum AFP levels, AST/ALT ratios, and prothrombin times may be useful as prognostic indices in patients with FHF.

並列關鍵字

fulminant hepatic failure ； charcoal hemoperfusion ； alpha fetoprotein ； AST/ALT ratio