We report a case of a 45-year-old female patient suffering from pruritus and prolonged yellowish skin discoloration. Laboratory studies disclosed a significant elevation of alk-p-tase, cholesterol and 1gM levels. Antimitochondrial antibody (AMA) was negative and antinuclear antibody (ANA) was positive. The endoscopic retrograde cholangiopancreatography (ERCP) was normal. Percutaneus needle liver biopsy was performed and the histopathological features confirm the diagnosis of autoimmune cholangitis, a variant of primary biliary cirrhosis (PBC).