Epidemiological Study on Hepatitis B Virus infection in Taiwan

在臺灣B型肝炎病毒感染之流行病學的研究

宋瑞樓(Juei-Low Sung) ； 陳定信(Ding-Shinn Chen) ； 賴明陽(Ming-Yang Lai) ； 余瑞雲(Jui-Yun Yu) ； 王德宏(Teh-Hong Wang) ； 王正一(Cheng-Yi Wang) ； 楊鼎勳 ； 李慶雲(Chign-Yun Lee) ； 陳森輝(Shen-Hui Chen) ； 柯滄銘(Tsang-Ming Ko)

《中華民國消化系醫學會雜誌》 1卷1期 (1984/01) Pp. 1-9

https://doi.org/10.6557/GJTa.198401_1(1).0001

摘要

對於0至70歲以上的無症狀帶有B型肝炎病毒表面抗原（簡稱S抗原）1,354名之血清及36名新生兒之臍帶血清以同位素分析法檢驗B型肝炎病毒之S抗原，其抗體（S抗體）及核心抗體（C抗體），結果1歲以下之嬰兒S抗原及C抗體陽性率各高至14.6%及16.6%，而S抗體為4.2%。2至4歲之間S抗原及C抗體陽性率高至35.4%。以後C抗體陽性率不斷的繼續上昇，在40~49達到88%，顯示在臺國人之B型肝炎病毒感染之盛行。相反的S抗原陽性率減少，5至9歲間變成20.0%，以後繼續保持20~17%至30~39歲，但其後漸漸減少，50~59歲後降至8.6%。S抗體陽性率15歲以後開始隨C抗體陽性率之上昇而上昇，於50~59歲昇至77.9%，以後不變，其與C抗體陽性率間之相差約與S抗原陽性率相近。
e抗原在無症狀S抗原帶原者296名中之陽性率為31.3%，在20歲以前高達70%以上。孕婦761名中S抗原陽性率為16.7%，其中85名帶原孕婦之e抗原陽性率為42.3%，這些事實才是使中國人繼續發生高度慢性S抗原帶原率之主因。

並列摘要

The determination of hepatitis B surface antigen (HBsAg), its antibody (anti-HBs) and antibody to hepatitis B core antigen (anti-HBc) were performed on sera from 1,354 healthy persons aged 0 to over 70 years and 36 cord blood specimens using radioimmunoassay. The positive rate of HBsAg was 14.6% accompanied with positive rate of anti-HBc in 16.6% but anti-HBs in only 4.2% between 0-1 year of age. Then the positive rates of both HBsAg and anti-HBc went u to 35.7% between 2-4 years of age. Thereafter the positive rate of anti-HBc continued to increase steadily up to over 88% after 40 years of age. On the contrary, the positive rate of HBsAg dropped to 20.0% between 5-9 years of age, then remained to be over 17% before 40 years of age and thereafter decreased gradztally down to 8.6% in the eighth decade. After 10-14 years of age, the differences of positive rates between anti-HBc and anti-HBs by age nearly equal to the positive rates of HBsAg in every age group. In Taiwan, the number of HBsAg carriers is estimated to be 2.9 millions.
The hepatitis B e antigen (HBeAg)-positive rate in 296 asymptomatic carriers of HBsAg was as high as 31.1% with very high rate of 74.4% and 69.5% in the first and second decades respectively. Among 761 pregnant women HBsAg was positive in 16.7%, and among 85 cases out of those HBsAg-positives HBeAg was positive in 42.3%; the high prevalence rate of HBsAg-and HBeAg-positives in pregnant women is the most important contributing factor of the high carrier rate of HBsAg in Chinese.

並列關鍵字

hepatitis B virus markers ； asymptomatic carrier of hepatitis B surface antigen ； epidemiology