臺灣慢性肝病與肝細胞癌病人δ病原體感染情況之研究

δ-Agent Infection in Chronic Liver Diseases in Taiwan

陳定信(Ding-Shinn Chen) ； 賴明陽(Ming-Yang Lai) ； 宋瑞樓(Juei-Low Sung)

《中華民國消化系醫學會雜誌》 1卷1期 (1984/01) Pp. 10-12

https://doi.org/10.6557/GJTa.198401_1(1).0002

摘要

我國人B型肝炎病毒感染極為常見，慢性帶B型肝炎表面抗原(HBsAg)者甚多，且國人死亡原用中肇因於慢性B型肝炎感染之肝硬化及肝細胞癌極為常見o為研討6病原體在我國此種病人致病之可能情況，於45例HBsAg陽性慢性活動性肝炎病例，4例HBsAg 陽性慢性持續性肝炎病例及11例HBsAg陽性肝細胞癌病例，以阻斷式放射免疫分析法測試血中δ抗體，並以免疫螢光法則試23例病人肝組織切片中δ抗原。結果僅發現3例慢性活動性肝炎病人為δ抗體陽性，佔6.7%，δ抗體於全體HBsAg陽性病例之出現率為5%。於所有肝組織中δ抗原皆要陰性。此一結果較大部份西方國家之報告為低，顯示δ病原體在國人慢性病並未扮演重要角色。

關鍵字

δ agent infection ； HBsAg-positioe chronic lioer disease

並列摘要

The δ agent infects humans only in the presence of hepatitis B virus (HBV), and contributes to the progressive liver damage in chronic HBV infection in some areas of the world. In Taiwan, chronic HBV infection is common, and an extremely high prevalence of hepatitis B surface antigen (HBsAg) carrier rate has been well-recognized. To assess the role of δ agent infection in our patients with chronic liver diseases, we studied 65 patients. There were were 45 HBsAg-positive patients with chronic active hepatitis, 4 with HBsAg-positive chronic persistent hepatitis, and 11. with HBsAg-positive hepatocellular carcinoma. Serum samples were studied for δ antibody by radioimmunoassay, and liver tissues from 23 of the patients were studied for δ antigen by direct immunofluorescence. δ Antibody was found only in 3 patients with HBsAg-positive chronic active hepatitis (6.7%) and an overall prevaleece of δ antibody was 5% in HBsAg-positive chronic hepatitis and hepatocellular carcinoma. None of the tissues studied showed an intrahepatic expression of δ antigen. The study indicates that δ agent does not seem to play an important role in chronic liver diseases and hepatocarcinoma. in the Chinese on Taiwan, despite a highly prevalent persistent HBV infection.