A Randomized Controlled Study of Triglycyl-Vasopressin and Vasopressin Plus Nitroglycerin in the Control of Acute Esophageal Variceal Hemorrhage

三氨基乙醯血管昇壓素與血管昇壓素合併三硝酸甘油控制急性食道靜脈曲張出血之隨機對照研究

李發耀(Fa-Yauh Lee) ； 蔡養德(Yang-Te Tsai) ； 黎國洪(Kwok-Hung Las) ； 賴啓賢(Chii-Shyan Lay) ； 張定宗(Ting-Tsung Chang) ； 馬里克(Usman Malik) ； 林勤益(Ching-Yih Lin) ； 李壽東(Shou-Dong Lee)

《中華民國消化系醫學會雜誌》 5卷3期 (1988/09) Pp. 131-138

https://doi.org/10.6557/GJTa.198809_5(3).0001

摘要

In a randomized controlled trial, the effect of triglycyl-vasopressin (glypressin) was compared with vasopressin plus sublingual nitroglycerin in 45 cirrhotic patients with bleeding esophageal varices. The two groups of patients were similarly matched for all parameters. Bleeding was controlled initiallyin52% (11/21) and 58% (14/24) of the patients treated with glypressin and vasopressin plus nitroglycerin, respectively (p＞0.05). Complete control of bleeding during 24 hr of drug infusion was achieved in only 4(19%) patients receiving glypressin and in 8 (33%) of those treated with vasopressin plus nitroglycerin (p＞0.05). Complications associated with drug infusion were significantly lower in the glypressin than in the vasopressin plus nitroglycerin groups (2/21vs 10/24, p＜0.0l). Mortality in relation to variceal bleeding and transfusion requirements were similar in the two groups. This study shows that glypressin alone is as effective as vasopressin plus nitroglycerin in controlling variceal bleeding. Glypressin has fewer complications than vasopressin plus nitroglycerin.

關鍵字

三氨基乙醯血管升壓素 ； 血管升壓素 ； 食道靜脈曲張出血

並列摘要

無資料

並列關鍵字

triglycyl-vasopressin (glypressin) ； vasopressin ； variceal bleeding