A 65 years old patient with epigastric and right upper abdominal pain was misdiagnosed as pancreatic carcinoma by endoscopic retrograde pancreatography and exploratory laparotomy. Abdominal pain still bothered him off and on for the following 7 years after by-pass operation. He received detailed examination again and was finally proved to have pancreas divisum and choledocholithiasis. The clinical presentations of pancreas divisum were discussed.