The Effect of Bile Anions on Bile Flow in Rats

老鼠膽汁中陰離子對膽汁流量之影響

張簡吉幸(Chi-Sin Changchien) ； 蕭逸夫(Yih-Fu Shiau)

《中華民國消化系醫學會雜誌》 8卷3期 (1991/09) Pp. 165-171

https://doi.org/10.6557/GJTa.199109_8(3).0002

摘要

To evaluate the relationship between bile flow and anions in bile, bile was collected through common bile duct of rat every 30 minutes for 270 minutes with or without ileal perfusion of taurocholate and/or electrolytes solutions. In group A as control, bile flow did not decrease without any replacement of bile salt or electrolyte through ileum. The bile flow was found to have good lineal regression with chloride in bile (R=0.99), then with bicarbonate (R=0.78). In group B, with ileal perfusion (rate 2 ml/hour) of taurocholate (40 mM) and electrolytes solution, the increase of bile flow was accompanied with significant increase of bile acid, bicarbonate and chloride in bile. The relations between bile flow and bile acid (R=0.73), and between bile flow and bicarbonate (R=0.94) became better than those (R=0.43, 0.78) in control group. In group C, with ileal perfusion (rate 2 ml/hour) of electrolytes (NaCl 100 mM and NaHCO3 40 mM) solution, the results were the same as in group A. On the results of this experiment, it is true that bile acids increase choleresis. Because chloride in bile showed better correlation with bile flow than bile acid, we consider, therefore, that electrolytes such as chloride and bicarbonate in bile may be induced by bile acid and result in hypercholeresis.

關鍵字

膽汁流量 ； 膽汁酸 ； 膽汁分泌

並列摘要

To evaluate the relationship between bile flow and anions in bile, bile was collected through common bile duct of rat every 30 minutes for 270 minutes with or without ileal perfusion of taurocholate and/or electrolytes solutions. In group A as control, bile flow did not decrease without any replacement of bile salt or electrolyte through ileum. The bile flow was found to have good lineal regression with chloride in bile (R=0.99), then with bicarbonate (R=0.78). In group B, with ileal perfusion (rate 2 ml/hour) of taurocholate (40 mM) and electrolytes solution, the increase of bile flow was accompanied with significant increase of bile acid, bicarbonate and chloride in bile. The relations between bile flow and bile acid (R=0.73), and between bile flow and bicarbonate (R=0.94) became better than those (R=0.43, 0.78) in control group. In group C, with ileal perfusion (rate 2 ml/hour) of electrolytes (NaCl 100 mM and NaHCO3 40 mM) solution, the results were the same as in group A. On the results of this experiment, it is true that bile acids increase choleresis. Because chloride in bile showed better correlation with bile flow than bile acid, we consider, therefore, that electrolytes such as chloride and bicarbonate in bile may be induced by bile acid and result in hypercholeresis.

並列關鍵字

bile flow ； bile salt ； Choleresis