Effect of Domperidone in Patients with Nonulcer Dyspepsia: A Double-Blind, Placebocontrolled Study

Domperidone對非潰瘍性消化不良療效之雙盲性試驗

張繼森(Chi-Sen Chang) ； 陳儉鏗(Gran-Hum Chen) ； 高嘉鴻(Chia-Hung Kao) ； 王燕良(Yen-Liang Wang) ； 王世楨(Shyn-Jen Wang)

《中華民國消化系醫學會雜誌》 9卷2期 (1992/06) Pp. 137-143

https://doi.org/10.6557/GJTa.199206_9(2).0005

摘要

Thirty patients with non-ulcer dyspepsia were included in a 4-week controlled double-blind trial of domperidone and a placebo. A questionnaire concerning symptoms was completed at the beginning of the study and after 4 weeks of treatment. Studies of gastric emptying, using a Tc-99m-labeled solid-phase meal, were performed at baseline and after 4 weeks of treatment. After 4 weeks of treatment, the symptom scores were significantly improved in the domperidone group (p＜0.01), and also in the placebo group (p＜0.05). Thirteen patients (43.3%) had abnormal gastric emptying at baseline, defined as a half-emptying time of mean ±1 SD (from studies of normal controls). There was a moderate improvement in the half-emptying time in the domperidone group (p＜0.05), but the correlation between improvement of gastric emptying and symptom scores was not statistically significant. The results of our study showed that 1)domperidone was an effective drug for the treatment of the symptoms of non-ulcer dyspepsia, and 2) that a radioisotopic gastric emptying study may be used as an objective method for identifying patients with abnormal gastric emptying.

關鍵字

非潰瘍性消化不良 ； 胃排空時間 ； Domperidone

並列摘要

Thirty patients with non-ulcer dyspepsia were included in a 4-week controlled double-blind trial of domperidone and a placebo. A questionnaire concerning symptoms was completed at the beginning of the study and after 4 weeks of treatment. Studies of gastric emptying, using a Tc-99m-labeled solid-phase meal, were performed at baseline and after 4 weeks of treatment. After 4 weeks of treatment, the symptom scores were significantly improved in the domperidone group (p＜0.01), and also in the placebo group (p＜0.05). Thirteen patients (43.3%) had abnormal gastric emptying at baseline, defined as a half-emptying time of mean ±1 SD (from studies of normal controls). There was a moderate improvement in the half-emptying time in the domperidone group (p＜0.05), but the correlation between improvement of gastric emptying and symptom scores was not statistically significant. The results of our study showed that 1)domperidone was an effective drug for the treatment of the symptoms of non-ulcer dyspepsia, and 2) that a radioisotopic gastric emptying study may be used as an objective method for identifying patients with abnormal gastric emptying.

並列關鍵字

Non-ulcer dyspepsia ； Gastric emptying ； Domperidone