- 期刊
瓦斯康溶液(Simethicone Solution)對上胃腸道內視鏡檢查的效用：雙盲式抽樣試驗
Effectiveness of Simethicone Solution in Upper Gastrointestinal Endoscopy: A Double-Blind, Randomized Study
摘要
操作內視鏡檢查時，常會因氣泡而影響觀察，尤其必須詳細觀察有無微小的黏膜病灶時，瓦斯康是最常被用來清除氣泡的藥劑，因而許多內視鏡檢查中心，都會常規地於術前準備時，給予瓦斯康以减少氣泡所引起之困擾，本研究之目的是希望找出上腸胃道內視鏡檢術前，瓦斯康給藥最經濟且有效之劑量。本研究共有200位病人，男性112人，女性78人，以隨機取樣的方法分成十組，每組給予瓦斯康溶液（25至20mg）或不含瓦斯康的水，在食道、胃、十二指腸（做過部份胃切除手術的患者，則以空腸代替十二指腸）各部位分別依氣泡及模糊度計分。在本研究中發現瓦斯康50mg至200mg配製成10ml或30ml溶液，皆能有效的减輕模糊度，並改善氣泡對上消化道內視鏡檢查之影響，各組中雖然以第四組100mg瓦斯康配製成10ml溶液之分數最低，但與其它各組瓦斯康溶液比較，並無統計上之差異。此外，瓦斯康25mg配製成10ml溶液或瓦斯康原液2.5 ml(50mg)，效果不如其他各組瓦斯康溶液；因此本研究之結論爲，瓦斯康能有效改善上消化道內視鏡檢時，氣泡所産生的困擾，而最經濟有效之瓦斯康劑量爲50mg配製成10ml或30ml之溶液。
並列摘要
Air bubbles may interfere the observation during an upper gastrointestinal endoscopy. Simethicone is commonly used preendoscopically to overcome this problem. The purpose of this study was to evaluate the effectiveness of simethicone in upper gastrointestinal endoscopy and to find the most cost-effective dosage. Two hundred patients were enrolled for this stady. All patients were randomized into 10 groups to receive water or various dosage of simethicone (50 mg to 200 mg). Scores for bubbles and hazziness were evaluated in the esophagus, stomach and duodenum (or jejunum for those who had previous subtotal gastrectomy). There was a significant difference between the simethicone group (group 3, 4, 5, 8 and 9) and the control group (group 1 and 7) (P＜0.05, one-way ANOVA). Although the lowest score was noted in group 4 (100 mg simethicone in 10 ml water), there was no significant difference among various dosage of simethicone (50 to 200 mg in 10 ml or 30 ml water). However, 25 mg simethicone in 10 ml water, or 50 mg simethicone in 2.5 ml solution did not improve the hazard caused by the bubbles. The results of this study showed that simethicone was effective to improve the observation of the upper gastrointestinal endoscopy. The most cost-effective dosage for the simethicone was 50 mg in 10 ml or 30 ml of water.