C型肝炎與第二型糖尿病在流行病學上的相關性已被注意。C型肝炎病毒的感染可能藉由原發炎細胞激素(Proinflammatory cytokine)的作用造成胰島素抗性上升及高血糖,而干擾素α(Inteferon-α)的治療可能造成胰島素分泌的缺損,甚至造成第一型糖尿病的發生。干擾素所造成的胰島素分泌缺損被認為是干擾素所誘發之胰島自發抗體(Islet autoantibody)所造成的。於此我們報告了一位無輕女性,本身有慢性C型肝炎及一次C型肝炎急性發作的病史,在接受干擾素治療的一年內,發生糖尿病及糖尿病酮酸血症,同時發現顯著之胰島素缺乏。
Background: HCV infection is very common in patients with diabetes, and interferon-α which is used to treat chronic hepatitis C may cause hyperglycemia secondary to insulin resistance or β-cell deficiency. We report a 24 year-old woman with chronic hepatitis C who received interferon-ct therapy for 6 months. She had no history of diabetes, but 4 months after completion of the interferon treatment, she had an episode of diabetic ketoacidosis and subsequently required chronic insulin therapy.