This study is to examine the early relation between of Sino-American, to find out the Factors that influence American decision making. There are five perspectives as: American's cognitive of Chinese, the attractive of China market, Me-too tradition, Open Door policy, and the effects of missionaries, etc. Among those factors, the most important one is the American's perspectives of Chinese, it follows different attitudes and policies of each president. Economic factor of China market is the second one. Ultimately, according to the time and space development, under Me Too tradition, the Open Door Policy became the major thematic as the principle of every president. It is the way to track back the current Sino-American relation.