This study focuses on the heat and mass transfer performance of the dehumidification system under periodic change of environmental pressure. Based on some available literatures, high environmental pressure will enhance the performance of absorption dehumidification, but will prolong the time of desorption regeneration. For better performance, we will operate adsorption in high environmental pressure, and desorption in atmospheric environmental pressure. Currently, in most of the dehumidifier, desiccant is designed as uniformly coated in the system. In fact, uniform coated is not a good design. During the adsorption process, most of the adsorbent will be adsorbed around air inlet, which means that desiccant around outlet or in the middle of the system doesn’t contribute well to the system performance. Our motivation is coating desiccant unevenly, in order to increase system performance.