Finding the stable Al3 (Ti, Zr, Sc) precipitates to enhance high-temperature applications of Al alloys is the goal of this study. The rapidly solidified technology is used in this study to get the Al-Ti-Zr-Sc ribbons with different compositions. Some of the specimens are vacuum sealed in quartz tubes and annealed at 425℃ for a long period of time. The coarsening phenomenon and phase transformation of L12-structured Al3 (Ti, Zr, Sc) precipitates are investigated by TEM observation. Moreover, the hardness of these alloys are examined. All of these would help us to further understand the potential of high-temperature application of these Al-Ti-Zr-Sc alloys.