Evaluation of the β Catenin Expression in the Oral Squamous Cell Carcinoma

口腔鱗狀細胞癌中β Cotenin表現之分析

黃則達(Tze-Ta Huang) ； 曾志恩(Jeh-En Tzeng) ； 黃穰基(Young-Kie Wang)

《臺灣口腔顎面外科學會雜誌》 19卷1期 (2008/03) Pp. 10-18

https://doi.org/10.7104/TJOMS.200803.0010

摘要

Objective: To evaluate the relationship between the catenin expression and the disease of oral squamous cell carcinoma. Materials and Methods: Fifty-two subjects who had received tumor ablative surgery and had complete medical records of the oral squamous cell carcinoma were selected from 2000 to 2002 in Buddhist Dalin Tzu Chi General Hospital, Taiwan. The expressions of catenin in these tumor cells were analyzed immunohistochemically. Results: The results show that the expressions of the catenin were slightly increased in these 52 cases. There were 28 cases (53.8%) which exhibited positive staining. After analyzing these data with Chi-square analysis, the expression of catenin was not statistically related to gender, site, tumor differentiation, cervical metastasis, clinical stages, distant metastasis, survival or personal habits (p＞0.05). Conclusions: This study shows that the expression of catenin was slightly increased in oral squamous cell carcinoma, but failed to show a specific relationship to the tumor progression.

關鍵字

β catenin ； 口腔癌 ； 免疫組織化學分析

並列摘要

Objective: To evaluate the relationship between the catenin expression and the disease of oral squamous cell carcinoma. Materials and Methods: Fifty-two subjects who had received tumor ablative surgery and had complete medical records of the oral squamous cell carcinoma were selected from 2000 to 2002 in Buddhist Dalin Tzu Chi General Hospital, Taiwan. The expressions of catenin in these tumor cells were analyzed immunohistochemically. Results: The results show that the expressions of the catenin were slightly increased in these 52 cases. There were 28 cases (53.8%) which exhibited positive staining. After analyzing these data with Chi-square analysis, the expression of catenin was not statistically related to gender, site, tumor differentiation, cervical metastasis, clinical stages, distant metastasis, survival or personal habits (p＞0.05). Conclusions: This study shows that the expression of catenin was slightly increased in oral squamous cell carcinoma, but failed to show a specific relationship to the tumor progression.

並列關鍵字

β catenin ； oral cancer ； immunohistochemistry