- 期刊
合併副甲狀腺素治療於長期使用注射型雙磷酸藥物引起之顎骨壞死－病例報告
Combination with Synthetic Parathyroid Hormone Treatment in Intravenous Bisphosphonate Related Osteonecrosis of Jaw-A Case Report
摘要
本病例報告一位有骨性轉移的乳癌病患，長期使用注射型的雙磷酸鹽藥物(Aredia(上標 ®))3年，因右下第二小臼齒患有牙周病，在診所拔除經4個月傷口仍無法癒合，並有膿腫、疼痛等現象，轉診到本科，經合併副甲狀線激素Forteo(上標 ®)(teriparatide)每支內含3.3ml（每ml含250mcg的teriparatide）的筆型注射的藥劑，每天以20單位(20mcg teriparatide)注射於腹部皮下組織爲期一個月，再經一個月後予以清創治療並經半年追蹤，傷口完全癒合，並推論此藥物在顎骨修復上的治療經驗報告。
並列摘要
A 46 y/o female, the diagnosis was breast cancer with bone metastasis, using Aredia(superscript ®) intravenous injection control bony metastasis for 3 years. Due to right lower second premolar was victim of severely periodontitis, extracted and treatment at local dentist. Unfortunately, the wound unhealing with redness, pus discharge continuous for 4 months, refer by general surgeon to our department. Under recombinant of human parathyroid hormone (rhPTH) submucosa injection one month and then wound debridement treatment, the wound gradually healing in 2 months follow up. 4 months later the new bone formation was formed. In this paper we present the treatment procedure and make a literature review about the rhPTH efficiency in bone repair.
延伸閱讀
- Shieh, Y. S., Ting, P. Y., Lin, C. K., Tsai, F. C., Wang, Y. B., & Chen, Y. W. (2015). 雙磷酸鹽類藥物引發下顎骨骨壞死於不同狀況之治療過程－病例報告. 中華民國家庭牙醫學雜誌, 10(3), 14-23. https://doi.org/10.6566/JFD/2015.10(3).14
- 李正喆、陳羿貞（2009）。雙磷酸鹽類藥物相關顎骨壞死與牙科治療之關聯性。中華民國家庭牙醫學雜誌，4(2)，8-13。https://doi.org/10.6566/JFD/2009.4(2).8
- 健康世界編輯部（2020）。長期用雙磷酸鹽類抗骨鬆藥品，要注意有否顎骨壞死問題。健康世界，(523)，70-71。https://www.airitilibrary.com/Article/Detail?DocID=16077059-202007-202007240008-202007240008-70-71
- Chiu, C. T., Chuang, C. Y., Chang, S. W., & Chiu, H. Y. (2008). 口服雙磷酸鹽藥物引起顎骨骨性壞死的危險因子、預防與治療原則. 中華民國家庭牙醫學雜誌, 3(3), 20-28. https://doi.org/10.6566/JFD/2008.3(3).20
- 李俊翰、陳立愷、賴智信（2020）。Treatment of Osteonecrosis of the Jaw (ONJ) in Patients Being Treated with Targeted Anticancer Drugs: A Case Report。北市醫學雜誌，()，1-9。https://doi.org/10.6200/TCMJ.202201/PP.0040