Lymphomas are malignant neoplasm of the lymphocyte cell lines, They have traditionally been separated into 2 subtypes: Hodgkin's and non-Hodgkin's lymphoma (NHL), According to the World Health Organization (WHO) recent classification, follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, SLL/CLL are classified as indolent type and diffuse large B-cell lymphoma, Burkitt's lymphoma, atypical Burkitt's lymphoma and mantle cell lymphoma are aggressive type, Follicular lymphoma is a common neoplasm in western country, but relatively rare in Asia, In this article, we report a case of an unusual case of follicular lymphoma in oral cavity and review the literatures, Further discussion on the protocol of treatments and the prognostic factors were presented, The presentation of lymphomas to occur as a head and neck tumor is usually only an asymptomatic nodule or mass that may differ it from correct diagnosis, When a mass or swelling of unknown origin without other signs in the head and neck is found, a lymphoma is one of the possible diagnoses.