- 期刊
成人第二型糖尿病對口腔鱗狀細胞癌預後之影響
Effect of Type 2 Diabetes Mellitus on Prognosis of Oral Squamous Cell Carcinoma
摘要
糖尿病為文明社會中常見的慢性病，並且與多種惡性腫瘤包括肝癌、胰臟癌、大腸直腸癌、子宮內膜癌、及乳癌等有相當的關聯性。此外，亦有研究顯示罹患糖尿病將增加罹患頭頸部惡性腫瘤的風險並且降低存活率。本研究中，我們回溯了本院口腔顎面外科613位口腔癌病患（2002/1/1~2007/12/31），其中糖尿病患者為126人，非糖尿病患者為487人；分析後發現，患有糖尿病的口腔癌患者較易有頸部淋巴結轉移、以及較差的整體存活期和癌症專一存活期。我們亦發現在患有糖尿病的口腔癌患者中，頸部淋巴結轉移為影響存活的獨立因素。因此，嚴格的血糖控制及降血糖藥物的使用在這類患者身上更形重要，以期能改善預後及得到較佳的存活率。
並列摘要
Diabetes mellitus (DM) is a chronic disease, several cancers have been linked to DM, especially those involving liver, pancreas, colorectum, endometrium, and breast. Besides, the risk of developing head and neck cancer was also found significantly higher in patients with DM. In this study, we retrospectively examined 613 patients with OSCC (126 patients with DM, 487 non-DM) between January 1, 2002 to December 31, 2007. We found high rate of lymph node metastasis, worse overall survival (OS) and disease specific survival (DSS) in the diabetic OSCC group. We also found that cervical lymph node metastasis is an independent factor associated with mortality in diabetic OSCC patients. Therefore, individualized therapy in patients with DM is necessary, and strict control of blood sugar is important.
延伸閱讀
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