- 期刊
The Prognosis of Perineural Invasion in Early Stage Oral Squamous Cell Carcinoma-A Retrospective Study
具有神經侵犯之早期口腔鱗狀上皮細胞癌預後－回溯性研究報告
摘要
Perineural invasion (PNI) is considered to be a factor affecting recurrence and survival in oral squamous cell carcinoma (OSCC). In the National Comprehensive Cancer Network guidelines, PNI is considered a minor risk factor for adjuvant therapy. The effects of PNI in early stage OSCC have not been widely discussed. The aim of this study was to analyze the relationship between PNI and clinical outcome in early OSCC. This retrospective study analyzed the recurrence and mortality in 383 stage I or II OSCC cases, for the period 1997-2014, in which surgical treatment was used. The results revealed that PNI affected the 5-year disease-free survival and recurrence rates. When PNI was noted in early OSCC, the risk of recurrence rate increases to 1.863 times.
並列摘要
神經侵犯在口腔鱗狀上皮細胞癌中被認為是一個影響復發及存活的因子。在目前癌症治療指引中，神經侵犯被認為是一個接受輔助性治療的次要因子。在初期口腔癌中，目前文獻中討論神經侵犯所帶來的影響較少，因此本研究討論神經侵犯於早期口腔癌的案例中所帶來影響。本回潮性研究收集本院自1997年至2014年383例接受手術處理之早期口腔癌案例並分析其復發率及死亡率。本研究顯示神經侵犯會影響病患五年無病存活率，有較高的復發率。神經侵犯發生於早期口腔癌時，疾病復發風險增為1.863倍。
延伸閱讀
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- Shen, W. R. (2013). 舌鱗狀細胞癌的神經侵犯與神經生長因子表現 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2013.00906
- 蘭汶姍（2022）。口腔鱗狀細胞癌術後預後因素之回顧性分析〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/csmu202200194
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