Mandibular defects requiring reconstruction are commonly encountered in clinical settings and can be caused by resection of benign or malignant lesions, osteonecrosis, trauma, or nonunion of the bone after treatment of a mandibular fracture. A severe compound comminuted fracture of the mandible shows a tendency for nonunion after surgical treatment. A bone defect of the mandible can be reconstructed using several methods including a reconstruction plate, nonvascularized autogenous bone graft, and vascularized autogenous bone graft. We report the case of a patient with severe trauma resulting from a compound comminuted fracture of the mandible, and nonunion was noted after surgical treatment. We used a fibula osteoseptocutaneous free flap to reconstruct both soft tissue and bone defects. The patient recovered favorably and will undergo dental implant placement in the future.