According to the location and etiology, tooth discoloration can be classified as intrinsic, extrinsic, and a combination of both. This case reported a 26-year-old woman who asked for tooth whitening. After examination, we found that there were two kinds of discoloration of her teeth. The treatment plan was via the combination of non-vital tooth bleaching and home bleaching for improving tooth discoloration. Follow-up revealed good result. In addition, this article systemically reviews the diagnosis, treatment, and prognosis of tooth discoloration.