The basic of fiber lasers, principles, advantages and optical properties, are reviewed. To extend the fiber laser spectra from near-IR to visible and mid-IR, we review the frequency conversion techniques using both nonlinear crystals and Raman cells. Medical applications (in ophthalmic, urology, dermatology, dental, and cancer therapy) using fiber lasers in visible (530-700nm) and IR (1000-3000nm) are explored, in addition to the high-power RGB lasers for display and backlight applications. We also introduce the basic laser-matter interaction based on the laser parameters and tissue absorption properties.